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METHODS AND OBJECTS OF CHEMICAL ANALYSIS
An international journal devoted to all aspects of analytical chemistry ISSN 2413-6166 (Online), ISSN 1991-0290 (Print) |
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Applied Chemometric Method Based on H-Point Standard Addition Method (HPSAM) for Simultaneous Spectrophotometric Estimation of Binary Mixture |
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* Corresponding author University of Baghdad, Baghdad, Iraq; *e-mail: ruaa.m.m@ihcoedu.uobaghdad.edu.iq |
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Methods Objects Chem. Anal., 2025, 20(4), p. 318–323 https://doi.org/10.17721/moca.2025.318-323 The article is distributed under open access Creative Commons Attribution License CC BY 4.0. |
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Abstract
A new simultaneous spectrophotometric approach for determining mefenamic acid (Mef) and piroxicam (Pir) was developed using the H-point standard addition method (HPSAM). The addition of standard mefenamic acid solutions was monitored by measuring absorbance at 305.3 and 343.1 nm. The study found that mefenamic acid and piroxicam can be detected simultaneously in prepared combinations at concentration ratios ranging from 2:4 to 10:6 μg mL-1. The limit of detection LOD was found to be 0.007 μg mL-1 for Mef and Pir. The percentage recovery ranged from 96.9 to 108.5% for mefenamic acid and 93.9 to 111.3% for piroxicam, with satisfactory precision. The proposed method was effectively used to determine Mef and Pir in both pure and commercial formulations.
Keywords: chemometric, H-point standard addition method, mefenamic acid, piroxicam
Article language: En
Publisher: Taras Shevchenko National University, Kiev Ukraine
(Analytical chemistry department at Taras Shevchenko
National University, 64 Vladimirskaya STR., Kiev, 01601 UKRAINE)
analysis@univ.kiev.ua,
www.univ.kiev.ua,
+380 (44) 2393444
The journal is indexed in SCOPUS and Web of Science
The journal website: www.moca.net.ua
The articles in this journal are licensed under
CC BY 4.0
