The Oxidative Derivatization Method for the Spectrofluorimetric Determination of Periciazine in Pharmaceutical Preparations M.Ye. Blazheyevskiy*† , Yu.V. Scrypynets‡ , A.V. Yegorova‡ , V.P. Antonovich‡
	* Corresponding authors † National University of Pharmacy, 53 Pushkinska Str., Kharkiv, 61002, Ukraine; ‡ Bogatsky Physicochemical Institute, NAS of Ukraine, Lustdorfska doroga, 86, 65080, Odesa, Ukraine; *e-mail: blazejowski@ukr.net
	Methods Objects Chem. Anal., 2020, 15(1), p. 21-26 https://doi.org/10.17721/moca.2020.21-26
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Abstract

The oxidative derivatization method for the indirect spectrofluorimetric determination of Periciazine has been presented. Potassium hydrogenperoxymonosulfate (Oxone ®) is proposed as a derivatizing agent for Periciazine, yielding the strongly fluorescent Periciazine sulfoxide. A highly sensitive, simple and rapid method for determination of the Periciazine by fluorescence of its oxidation product with Oxone ® solution in 0.02 M hydrochloric acid solution (λ_ex = 364 nm; λ_em = 444 nm) has been developed. The calibration plot is linear in concentration range of 0.05 – 4.00 µg mL -1 . LOQ (10S) is 0.05 µg mL -1 . The possibility of quantitative determination of Periciazine in pharmaceutical preparations (Neuleptil ®, 10 mg capsules and Neuleptil ®, a 30 mL 4 % oral (solution) drops) has been shown RSD < 2.2 % (δ < RSD).

Keywords: spectrofluorimetry, Oxone, determination, periciazine, phenothiazine sulphoxide; pharmaceuticals

Article language: En