A New Oxidative Derivatization Method for the Indirect Spectrofluorimetric Determination of Prochlorperazine Maleate in Pharmaceutical Preparations M.Ye.Blazheyevskiy*†, Yu.V.Skrypynets‡, A.V.Yegorova‡, V.P.Antonovich‡
	* Corresponding authors † National University of Pharmacy, 53 Pushkinska str., Kharkiv, 61002, Ukraine; *e-mail: blazejowski@ukr.net ‡Bogatsky Physicochemical Institute, National Academy of Sciences of Ukraine, Lustdorfska doroga, 86, Odesa, 65080, Ukraine
	Methods Objects Chem. Anal., 2019, 14(3), p. 140-145 https://doi.org/10.17721/moca.2019.140-145
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Abstract

A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid solution (λ_ex = 340 nm; λ_em = 380 nm). The calibration curve is linear in its concentration range of 0.8–10.0 µg/ml. Limit of quantification (LOQ = 10S) is 0.8 µg/ml. The possibility of quantitative determination of Prochlorperazine maleate in Vertinex® tablets 5 mg has been shown, RSD <2.3% (δ <RSD).

Keywords: spectrofluorimetry, oxone, derivatization, prochlorperazine maleate, prochlorperazine sulphoxide, tablets

Article language: En