METHODS AND OBJECTS OF CHEMICAL ANALYSIS

An international journal devoted to all aspects of analytical chemistry

ISSN 2413-6166 (Online), ISSN 1991-0290 (Print)

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Quantitative Determination of Clindamycin and Clindamycin Phosphate by the Method of Iodometry using Peroxomonosulfate

M. Ye. Blazheyevskiy^†, D. Alfred-Ugbenbo*^‡, V.V. Diadchenko^§, V.P. Moroz^†, O.S. Kryskiv^†

^† Department of General Chemistry, National university of pharmacy, 61168, Kharkiv, Ukraine
^‡ Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Bayelsa Medical University P.M.B. 178 Imgbi Rd, Yenagoa, Bayelsa State, Nigeria
^§ Military Institute of Armored Forces of NTU "KhPI", 62472, Ukraine

* Corresponding author

*e-mail: audeghinmotei@gmail.com

Methods Objects Chem. Anal., 2026, 21(1), p. 14–22

https://doi.org/10.17721/moca.2026.14-22

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Abstract

The pH-dependent kinetics and mechanism of the oxidation reaction of clindamycin hydrochloride (CLN) with potassium hydrogen peroxomonosulfate (KHSO₅) at 20°C was studied in order to develop a novel assay method. It has been established that the reaction kinetics obey the general laws of specific acid-base catalysis. Stoichiometrically, KHSO₅ was found to react with CLN in an alkaline medium (pH 8.0–9.0), at a 3:1 mole ratio, to form the corresponding sulfone-N-oxide. Methods for the oxidimetric determination of CLN and Clindamycin phosphate (CLN-P) were developed using KHSO₅ as an analytical reagent: a known excess of the reagent is added and after a specified time its residual amount is determined by iodometry. The developed method was successfully used to determine clindamycin in dosage forms such as capsules and injection. RSD does not exceed 1.7%.

Keywords: clindamycin hydrochloride, clindamycin phosphate, iodometry, oxidimetric titration, oxone, potassium hydrogen peroxomonosulfate, assay

Article language: En

Publisher: Taras Shevchenko National University, Kiev Ukraine

(Analytical chemistry department at Taras Shevchenko National University, 64 Vladimirskaya STR., Kiev, 01601 UKRAINE)
analysis@univ.kiev.ua, www.univ.kiev.ua, +380 (44) 2393444

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