Abstract

A new method to uptake vitamin B12 in aqueous solution as pharmaceutical preparations by adsorption on the solid phase surface by using a multi-layer graphene oxide derivative compounds while the ultrasonic frequency wave was used to increase the efficiency of the extraction of drug from aqueous solution. Interlayer drug extraction conditions were optimized by studying a number of conditions that affect the extraction rate, including pH, ultrasound frequency, residence time of the solution inside the ultrasound device, the effect of the amount of graphene oxide derivative, and vitamin B12 concentration. The effect of temperature was also studied and a number of thermodynamic factors were generated. From the results, it was found that the best weight for the economically useful graphene oxide derivative is 0.01 grams at a concentration of 20 ppm relative to the concentration of the vitamin using an acidic medium of 2.1. The best temperature is 40 0C and within 50 Hz of the frequencies of the ultrasound device during the incubation period of 50 minutes. The proposed method was also applied to pharmaceutical samples containing vitamin B12, and the extraction rate was 95.35 %, with a very small error rate of 0.0465.

Keywords: vitamin B12, solid phase extraction, sonochemistry, fluorinated graphene oxide

Article language: En