METHODS AND OBJECTS OF CHEMICAL ANALYSIS ISSN title: "Metody i obʺekty himičeskogo analiza" An international journal devoted to all aspects of Analytical chemistry ISSN 2413-6166 (Online), ISSN 1991-0290 (Print)
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Zh. O. Kormosh, I. P. Hunka, Ya. R. Bazel,

 A new analytical form for the spectrophotometric determination of low levels of diclofenac

Volyn State University, Voli av., 13, 43025 Lutsk, Ukraine

Uzhgorod National University, Pidgirna str., 46, Uzhgorod, Ukraine 3

P.J. Safarik University, Moyzesova str., 11, 04154 Kosice, Slovakia

A new simple rapid and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium (Dicl). This method based on the reaction of diclofenac sodium with an analytical reagent 3-Methyl-2-[(E)-3-[1,3,3-trimethyl-3-H-indol-(2E)-ylidene]-propenyl]-benzothiazol-3-ium iodide (BIK) at pH 8.5– 10.5 and the extraction of ion associate colored complex. Optimal conditions for the complex formation between Dicl and BIK were studied. This ion associate complex (1:1) was detect and extracted with toluene and an absorption maximum at 566.2 nm against blank reagent. The calibration graph was linear from 0.6–10.0 μg·ml- 1 of diclofenac and the detection limit was 0.0035 μg·ml-1.

Keywords: diclofenac · ion associates · determination · spectrophotometry