METHODS AND OBJECTS OF CHEMICAL ANALYSIS ISSN title: "Metody i obʺekty himičeskogo analiza" An international journal devoted to all aspects of Analytical chemistry ISSN 2413-6166 (Online), ISSN 1991-0290 (Print)
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Comparison of different phosphorimetric techniques for the determination of pindolol in multi
ingredient mixtures

E. M. Rekharsky, A. P. Chukharkina, A. G. Borzenko

Lomonosov Moscow State University, Chemistry Department, Analytical Chemistry Division, Vorob'evy Gory, Moscow, 119992, Russia; e-mail: rekharsky@analyt.chem.msu.ru

The sensitivity of luminescence makes it useful analytical tool for monitoring compounds of biochemical interest such as drugs. In this work we examined the possibility of the determination of pindolol in multiingredient mixtures by measuring the phosphorescence intensity at room temperature in aqueous, homogeneous micellar and mixed micellar solutions. The best working conditions in the investigated systems were proposed for the determination of investigated drug in different mixtures. The qualities and limitations of each system are discussed. The results obtained in this work indicate that the analytical procedures based on the use of roomtemperature phosphorescence allow the determination of the pindolol in multi-ingredient mixtures.

Keywords: pindolol · beta-adrenoacceptor blocker · MS-RTP · HAI-RTP · mixed micelles