Potentiometric Sensor for Analgin Determination in Pharmaceutical formulations Z.A. Kormosh*†, T.I. Savchuk†, D.I. Semenishin‡, S.V. Suprunovich†,V.V. Kochubei‡, S.I. Korolchuk†
	* Corresponding authors † Eastern European National University, Voli av. 13, Lutsk 43021, Ukraine; ‡ Lviv Polytechnic National University, 12 S. Bandery st., 79016 Lviv, Ukraine *e-mail: zholt-1971@ukr.net
	Methods Objects Chem. Anal., 2020, 15(2), p. 66-72 https://doi.org/10.17721/moca.2020.66-72
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Abstract

Ion associates (IA) of butylrodamine C with triiodide and iod bromide have been synthesized. Their thermal behavior is investigated. Thermolysis synthesized by IA BR⁺I₃¯ passes through a number of intermediate stages, since the C₄H₉ radical, which is part of the dye, has a significant effect on the process of thermolysis of the ionic associate. IA BR⁺I₃^¯ begins to decompose significantly at a temperature higher than 140 ºC with an endothermic effect at 240 ºC and two small exothermic effects with a maximum at 282 ºC and 355 ºC (corresponding to the release of 2NH₃, 8C₂H₄, 2HI). In the range of 380–720 ºC, the exothermic effect of the IA combustion occurs at a temperature of 485 ºC with significant mass loss. The obtained IAs are stable under normal conditions. An I₃^¯ and I₂Br¯ sensor containing butyrodromine C associate of butylrodamine C with triiodide and iodum bromide was developed. The working interval of the pH of the triiodide sensor is 2 - 12, and for iodum bromide, the pH is 2 - 10, respectively. The linearity interval of the electrode function is in the range 9 ∙10^-6 - 1 ∙10^-1 mol L^-1, the slope is 65 mV/pC for the triiodide, and for the iodine bromide - 1 ∙10^-5 - 1 ∙10^-1 mol L^-1, the slope 68 mV/pC. The technique of potentiometric determination of analgin in medicines is developed.

keywords: triiodide sensor, iodide bromide sensor, potentiometry, analgin

Article language: Ukr