Analytical chemistry council


(Metody i Ob''ekty Himicheskogo Analiza)

An international journal devoted to all aspects of Analytical chemistry

ISSN 2413-6166 (Online), ISSN 1991-0290 (Print)

Kiev University

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The Study of the Electrochemical Behavior of Triamcinolone Acetonide on the Carbon Paste Electrodes for its Voltammetric Determination

P.M. Zagrzewski*, K.N. Belikov†‡, I.A. Zinchenko

* Corresponding authors
State Scientific Institution “Institute for Single Crystals” of NAS of Ukraine, Nauki ave, 60, Kharkiv, 61001, Ukraine;
V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine

Methods Objects Chem. Anal., 2018, 13(3), p. 136-140 

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The electrochemical properties of triamcinolone acetonide on carbon-paste electrodes have been studied. By the cyclic voltammetry method it was revealed that this steroid is irreversibly reduced at a potential from -0.9 to -1.4 V, depending on the solution pH and the potential sweep rate, while an increase in the sweep rate results in a shift of the peak position to more negative potentials. The limiting stage of the process of reducing triamcinolone acetonide on carbon-paste electrodes is diffusion. The calibration graph was linear in the concentration range from 2 to 46 μmol/L, the detection limit was 1.5 μmol/L. The possibility of using differential pulse voltammetry on carbon-paste electrodes for the determination of the active substance content in ampoules of a suspension of Kenalog 40 was shown.

Keywords: triamcinolone acetonide, triamcinolone, glucocorticosteroid, carbon-paste electrodes, cyclic
voltammetry, differential pulse voltammetry

Article language: Rus

Publisher:Taras Shevchenko National University, Kiev Ukraine

(Analytical chemistry department at Taras Shevchenko National University, 64 Vladimirskaya STR., Kiev, 01601 UKRAINE),, +380-44-2393345

Papers published in Methods and Objects of Chemical Analysis are considered as publications suitable for PhD thesis

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