Analytical chemistry council


(Metody i Ob''ekty Himicheskogo Analiza)

An international journal devoted to all aspects of Analytical chemistry

ISSN 2413-6166 (Online), ISSN 1991-0290 (Print)

Kiev University

Home Current issueArchiveCall for papars Contact us


Chromatographic Evaluation of the Lipophilic Properties of Some Derivated Acridin-9(10H)-one

Yu.V. Karpenko*, L.O. Omelyanchyk, T.V. Panasenko, A.R. Kuchmenko

* Corresponding author

Zaporizhzhia National University, Zhukovsky St., 66, Zaporizhzhia, 69014, Ukraine;

Methods Objects Chem. Anal., 2018, 13(3), p. 115-120

Buy Article:

2 USD plus tax


preview the article


Lipophilicities of the s-derivatives of 10-((5-mercapto-1,3,4-oxadiazol-2-yl)methyl)-2R-acridine-9(10H)-ones have been studied by various chromatographic methods and the results were compared with those obtained from the distribution method in binary n-octanol/water system. The linear relationships between the chromatographic parameters (tR, RM, logkW) of six reference substances and the newly synthesized compounds versus index of lipophilicity were determined. The parameters of lipophilicity obtained from the chromatographic methods (logPGCMS, logPTLC, logPLCMS) for new compounds were obtained by extrapolation. A correlation matrix was established between the experimental and calculated values of logP and found high correlation values between high performance liquid chromatography, the method of "shake flask" and theoretically calculated lipophilicity. The most rapid methods for determining lipophilicity, which provide high correlation coefficients between the theoretically calculated lipophilicity indices, are proposed.

Keywords: lipophilicity, acridine-9(10H)-one, 1,3,4-oxadiazole-2-thione, n-octanol, thin-layer chromatography, GCMS, LCMS

Article language: Ukr

Publisher:Taras Shevchenko National University, Kiev Ukraine

(Analytical chemistry department at Taras Shevchenko National University, 64 Vladimirskaya STR., Kiev, 01601 UKRAINE),, +380-44-2393345

Papers published in Methods and Objects of Chemical Analysis are considered as publications suitable for PhD thesis

The journal website: