Analytical chemistry council

Metody i Ob'ekty Khimicheskogo Analiza


Kiev University

An international journal devoted to all aspects of Analytical chemistry


ISSN 1991,0290

Ukr | En | Rus

Volume 3, No. 1, 2008

Ion Selective Electrode Based on Ion Associate with Basic Dye for the Potentiometric Determination of Diclofenac

Zh. O. Kormosh, I. P. Hunka, R. V. Krakovyak, Ya. R. Bazel

A simple, precise, rapid and low-cost potentiometric method for diclofenac determination in urine samples and pharmaceuticals is proposed. A new diclofenac-sensitive electrode was constructed by incorporating the diclofenac ion pair complex with rhodamine 6G into graphite matrix. The electrode exhibited a linear response over the concentration range of 110-4-510-2 mol L-1, a detection limit of 3.210-5 mol L-1 with a Nernstian slope of 59 2 mV decade-1. The working pH range is 6-11. The electrode is easily constructed, has fast response time (3- 10 s) and can be used for the period of five months without any considerable deterioration. The proposed sensor displays good sensitivity for diclofenac in the presence of several substances.

Keywords: diclofenac potentiometric sensors pharmaceutical analysis

Publisher: Analytical Chemistry Scientific Council of Ukraine

(Analytical chemistry department at Taras Shevchenko National University, 64 Vladimirskaya STR., Kiev, 01601 UKRAINE),, +380-44-2393345

Papers published in Methods and Objects of Chemical Analysis are considered as publications suitable for PhD thesis

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